・骨基質タンパク質オステオカルシンによる脂肪細胞の接着タンパクを標的にした新規肥満予防法の探索

・S. Mukai, A. Mizokami, T. Otani, T. Sano, M. Matsuda, S. Chishaki, J. Gao, T. Kawakubo-Yasukochi, R. Tang, T. Kanematsu, H. Takeuchi, E. Jimi, M. Hirata, Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis, J. Biol. Chem. (2021) 100274. 
・T. Otani, A. Mizokami, T. Kawakubo-Yasukochi, H. Takeuchi, T. Inai and M. Hirata, The roles of osteocalcin in lipid metabolism in adipose tissue and liver, Adv. Biol. Regul. 78 (2020) 100752.
・S. Miyazono, T. Otani, K. Ogata, N. Kitagawa, H. Iida, Y. Inai, T. Matsuura, T. Inai, The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium, Histochem. Cell Biol. 153 (2020) 225-237.
・A. Mizokami, S. Mukai, J. Gao, T. Kawakubo-Yasukochi, T. Otani, H. Takeuchi, E. Jimi and M. Hirata, GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin, J. Endocrinol. 244 (2020) 285-296.
・M. Nikaido, T. Otani, N. Kitagawa, K. Ogata, H. Iida, H. Anan and T. Inai, Anisomycin, a JNK and p38 activator, suppresses cell-cell junction formation in 2D cultures of K38 mouse keratinocyte cells and reduces claudin-7 expression, with an increase of paracellular permeability in 3D cultures, Histochem. Cell Biol. 151 (2019) 369-384.
・T. Otani, M. Matsuda, A. Mizokami, N. Kitagawa, H. Takeuchi, E.Jimi, T. Inai and M. Hirata, Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300, Cell Death Dis. 9 (2018) 1194.
・K. Nagano, H. Takeuchi, J. Gao, Y. Mori, T. Otani, D. Wang and M. Hirata, Tomosyn is a novel Akt substrate mediating insulin-dependent GLUT4 exocytosis, Int. J. Biochem. Cell. Biol. 62 (2015) 62-71.
・T. Otani, A. Mizokami, Y. Hayashi, J. Gao, Y. Mori, S. Nakamura, H. Takeuchi and M. Hirata, Signaling pathway for adiponectin expression in adipocytes by osteocalcin, Cell. Signal. 27 (2015) 532-544.